pagination(?) error and time sig error

Looks like you (inadvertently?) dragged bunch of the 4/4 time signatures way out of position. The worst culprit is one you apparently dragged all the way across the page, and that is what is destroying the layout. Click the greyed-out (invisible) 4/4 you see at the bottom of measure 38 and press Ctrl+R to return it to its proper position. Then you will see the doubled time signature that are indeed present in your score, but the layout will be correct otherwise.

If you can think of what steps might have led to those double time signatures being present, let us know. There were bugs in older builds (pre-release mostly) that could cause this on occasion, but I don't think we know of any way to reproduce this bug now. So most likely whatever bug led to this is already fixed and it won't happen again, but meanwhile you need to fix your score. One way to do that is add another 4/4 the next bar, then delete the double 4/4, save, and reload. Then you can add the missing 4/4 again and delete the extra one.